Takao T, Matsui A, Kikutake C, Kan-O K, Inoue A, Suyama M, Okamoto I, Ito M

Maternal asthma imprints fetal lung ILC2s via glucocorticoid signaling leading to worsened allergic airway inflammation in murine adult offspring.

Nat Commun 16(1): 631, 2025Pubmed

Ogata H, Tsubouchi K, Takano T, Ichiki K, Torii R, Takata S, Nakagaki N, Yoshida M, Kitasato Y, Tobino K, Harada E, Wataya H, Ishii H, Maeyama T, Kawasaki M, Fujita M, Yatera K, Zaizen Y, Nakanishi Y, Okamoto I

Mortality and exacerbation risk according to GOLD and STAR severity stages of COPD: a 5-year multicenter prospective cohort study.

Sci Rep 15(1): 19097, 2025Pubmed

Inoue S, Ogata H, Dotake Y, Takagi K, Shiota A, Ishii Y, Tanaka K, Kan-O K, Inoue H.

Tezepelumab achieves improvement of severe uncontrolled asthma and rhinosinusitis: Case series.

J Allergy Clin Immunol Glob 4(2): 100448, 2025Pubmed

Ishii Y, Shiota A, Takao T, Yamamoto N, Ogawa T, Jo A, Shinozaki S, Fukuyama S, Koga T, Ito M, Tanaka H, Tamura A, Tsukita S, Matsumoto K, Okamoto I, Kan-O K

Claudin-3 deficiency inhibits allergic responses in an ovalbumin-induced asthma mouse model.

Allergol Int 74(3): 472-475, 2025Pubmed

Inoue S, Nagao J, Kawamoto K, Kan-O K, Fukuyama S, Sasaki S, Kudo S, Okamoto I, Sera T

Overstretching alveolar epithelial type II cells decreases surfactant secretion via actin polymerization and intracellular trafficking alteration.

Heliyon 10(13): e33499, 2024Pubmed

Kawatoko K, Washio Y, Ohara T, Fukuyama S, Honda T, Hata J, Nakazawa T, Kan-O K, Inoue H, Matsumoto K, Nakao T, Kitazono T, Okamoto I, Ninomiya T

Risks of Dementia in a General Japanese Older Population With Preserved Ratio Impaired Spirometry: The Hisayama Study.

J Epidemiol 34(7): 331-339, 2024Pubmed

Kan-O K, Noda T, Ogata H, Masaki K, Nishioka Y, Myojin T, Adachi T, Morita H, Imamura T, Tamari M, Kainuma K

Insights from the trends of omalizumab and mepolizumab utilization in patients with asthma: A population-based cohort study using the National Database in Japan.

Respir Investig 62(1): 113-120, 2024Pubmed

Ogata H, Nakano H, Yanagihara T, Moriuchi Y, Enokizu-Ogawa A, Ishimatsu A, Otsuka J, Furukawa T, Taguchi K, Moriwaki A, Yoshida M

Preserved ratio impaired spirometry and severity of obstructive sleep apnea: An observational cross-sectional study.

Respir Med Nov-Dec: 234, 2024Pubmed

Nakahara S, Ishii Y, Egashira R, Tsubouchi K, Kohno M, Takenaka T, Tanaka K, Okamoto I

Lemborexant-induced interstitial lung disease: A case report.

Respirol Case Rep 12(5): e01334, 2024Pubmed

Kan-O K

Asthma-related death trends and biologics use for severe asthma in the super-aged society of Japan.

Respirology 29(6): 455-457, 2024Pubmed

Kan-O K, Washio Y, Oki T, Fujimoto T, Ninomiya T, Yoshida M, Fujita M, Nakanishi Y, Matsumoto K

Effects of treatment with corticosteroids on human rhinovirus-induced asthma exacerbations in pediatric inpatients: a prospective observational study.

BMC Pulm Med 23(1): 487, 2023Pubmed

Kawano H, Kan-O K, Egashira A, Okamoto I

Allergic bronchopulmonary aspergillosis manifested secondary to bacterial pleural empyema.

Respirol Case Rep 12(1): e01264, 2023Pubmed